Topic: mGluR-LTD

Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) is an important form of synaptic plasticity that occurs in many regions of the brain and is the underlying mechanism for several learning paradigms. In the hippocampus, mGluR-LTD is manifested by the weakening of synaptic transmission and elimination of dendritic spines. Interestingly, not all spines respond or undergo plasticity equally in response to mGluR-LTD. A subset of mature and more stable dendritic spines containing synaptopodin (SP), an actin-associated protein involved in local protein synthesis and calcium d

Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that underlie declarative memory by inducing long-term depression (mGluR-LTD). mGLUR-LTD results from an endocytosis of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) underlying synaptic depression. The lab has previously shown that mGluR5 specifically activates TRPC1 channel, a Transient Receptor Potential channel that is highly expressed in CA1-3 regions of the hippocampus.To investigate the role of mGluR-TRPC1 in synaptic plasticity, and to decipher its downstre