Topic: microelectrode recordings

The neocortex is built up from homologous neuron types, but neurons exhibit between-species differences in gene expression, molecular profile, and electrical function. Purpose of these specializations is not well understood. In human neocortex, fast-spiking interneurons have high electrical excitability compared to their rodent counterparts. This slows down time course for cell membrane potential changes, and in theory, makes human fast-spiking neurons slower than rodent cells to process electrical input signals and generate action potential (AP). However, human neurons are nearly as fast with

Genetic dystonia is a complex movement disorder with diverse clinical manifestations arising from pathogenic mutations in various genes. The growing body of research indicates shared pathomechanism among these genes, yet the neural dynamics facilitating this convergence are largely unexplored. We analyzed neural patterns within globus pallidus to identify shared neural dynamics underlying functional convergence across dystonia genes. We identified 1714 pallidal neurons, isolated from explorative microelectrode recordings collected during deep brain stimulation surgery, across 32 dystonic patie