Topic: microfluidic technology

Implantation and integration of human neural stem cells (hNSCs) to mouse host brains has been reported by previous studies. We are interested in generating a pre-organised construct from hNSCs that contains progenitors with different cerebral cortical layer identity using 3D printing technologies (Jin et al., Nat Commun 14, 5986 (2023). We optimised a sequential isolation protocol of lower and upper cortical layer specific hNSCs generated from human pluripotent stem cells (hPSCs). We confirmed the ability of these cells to generate neurons of the upper or lower cortical layers both in vitro an

Our group recently developed a technology for non-invasive hyperconcentrated (1’300x) focal drug delivery to the brain without opening the blood-brain barrier (BBB), reducing off-target effects significantly [1]. This study aims to investigate and improve the dynamics of focally hyperconcentrated drug release mechanisms using focused ultrasound (FUS) technology and ultrasound-sensitive drug carriers. Firstly, to achieve high concentration of drug release, we designed and manufactured ultrasound-sensitive drug carriers using microfluidic technology, allowing us to have control over size and con