Topic: microglia depletion

Identification of Alzheimer's disease (AD) risk loci highlighted the role of microglia in the pathogenies of AD. Nevertheless, whether microglia are beneficial or detrimental in AD is still debated. Several studies tested the contribution of microglia to amyloid pathology by microglia depletion, resulting in seemingly contradictory results. Here, we aimed to unify these conflicting findings by systematically testing microglia depletion at various stages of disease progression in mice.Depletion of microglia by PLX3397 treatment before the onset of amyloid plaques in AppNL-G-F mice resulted in a

Cancer survivors treated with chemotherapy experience persistent memory deficits, commonly known as ‘chemofog’. Currently there are no effective treatments for chemotherapy-induced cognitive impairment, and the underlying molecular mechanisms are poorly understood. Recent evidence suggests that chemotherapy induces chronic microglia reactivity, the brain’s resident immune cells, which could drive alterations in neuroplasticity mechanisms ultimately causing memory impairment. In this study we want to investigate the role of microglia in chemotherapy-induced learning and memory impairment in a r