Topic: microglial reactivity

Microglial reactivity is linked with the loss of dopaminergic (DA) neurons in Parkinson’s disease (PD). In this context, we propose that calcium, potentially released by DA dying neurons to the extracellular space, may contribute provoking changes in microglial polarization.Postmortem samples from PD patients exhibited increased microglia-neuron interactions in the Substantia Nigra (SN) when compared with control individuals, indicating a polarization of microglia in this pathological scenario. Besides, MPTP-treated parkinsonian mice also revealed a significant number of polarized microglia to

Following injury, astrocytes undergo major alterations in morphology and gene expression, leading to the acquisition of distinct “reactivity” states that play important roles in brain tissue repair. Evidence indicates that these cellular states are also marked by rewiring of mitochondrial energy metabolism, i.e. the central hub for cellular energy metabolism and metabolic signaling. However, how such mitochondrial responses are regulated and how they may influence astrocyte reactivity remains unclear. Our prior research unveiled temporal and region-specific morphological changes in astrocytic