Topic: microRNA

Alzheimer's Disease (AD) is a complex and progressive neurodegenerative disorder that affects millions of people worldwide. However, current treatments and diagnostic methods are ineffective in early detection and intervention. Recently, researchers have focused on the dysregulation of small non-protein-coding microRNA (miRNA) and the associated post-transcriptional gene alteration in AD. Biofluids, such as serum and cerebrospinal fluid, contain miRNAs that can be identified and quantified. The project aims to identify circulating miRNAs within serum and CSF, which can be used as non-invasive

Pre-reproductive stress affects behavior as well as mRNA and microRNA (miRNA) expression in adolescent female rats and their offspring in a sex-dependent-manner. Transfer RNAs (tRNAs), non-coding RNAs (ncRNAs) consisting of 70-90 nucleotides, play a role in regulating protein translation and were recently implicated in stress-related brain function and transgenerational information transfer. tRNAs may be cleaved into tRNA halves or fragmented into smaller tRNA fragments (tRFs). Here, we asked whether pre-reproductive chronic unpredictable stress (CUS) impacts the expression of full-length tRNA