Topic: midcingulate cortex

A critical advance in neuroscience is the ability to intervene reversibly in a pathway-specific manner on interactions between brain regions, providing understanding of the causal role of those interactions, but also moving us towards targeted therapies for pathologies linked to neural pathways. We present data on pathway-specific DREADDs (Designer Receptor Exclusively Activated by Designer Drugs) in macaque monkeys. This approach is only now emerging for primates, and permits the targeted modulation of a specific neural pathway over a period of hours. We conducted two DREADD experiments to sp

Learning to learn is a separate function from classical learning, which makes our learning more efficient and flexible. It is particularly associated with primates (Harlow, 1953) and linked to the lateral prefrontal cortex (LPFC) by lesions studies (Browning et al., 2007). LPFC forms an interacting circuit with the midcingulate cortex (MCC) which plays an important role in outcome and performance evaluation (Procyk et al., 2016). Most electrophysiological recordings are made after extensive training, so they ignore neurophysiological changes that permit learning to learn. This project identifi