Topic: miniature excitatory postsynaptic currents

CLN3 is a lysosomal membrane protein whose precise function is not yet known. Recent studies propose divergent functions for CLN3; as a vesicular trafficking hub or its role in glycerophosphodiester (GPD) efflux from lysosomes. The role of CLN3 in the neurons and at the synapse remains elusive. Mutations in CLN3 gene cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), a condition associated with learning impairments and memory deficits in affected children. Using CLN3Δex7/8 mouse model, we investigated the impact of CLN3 loss at synapses. Analysis of synaptic transmission revealed a signific

The perirhinal cortex (PER) integrates and transfers information from cortical areas to the hippocampus, which is crucial for memory-related tasks, particularly novel object recognition. However, how the PER gates information transfer is largely unknown. During learning and novelty-induced exploration, the locus coeruleus releases noradrenaline, a candidate for modulating synaptic plasticity within the PER. We explored the hypothesis that noradrenaline could transiently increase the excitability of the PER network, enhancing information transfer toward the hippocampus and ultimately leading to