Topic: Miniature inhibitory postsynaptic currents

GABAergic interneurons (INs) highly impact cortical development. For instance, early postnatal dysregulation of vasoactive intestinal polypeptide (VIP)- expressing GABAergic INs has been shown to impair sensory processing and learning, emerging from adolescence on. Thus, investigating the functional maturation and network integration of VIP-INs is important for understanding brain development. Here, we studied developmental changes in passive and active membrane parameters of VIP-INs and their network integration into the developing neocortex with an emphasised focus on the maturation of their

Glyphosate (Gly)-based herbicides (GBH), which are widely used worldwide, work by inhibiting the enzyme enolpyruvylshikimate-3-phosphate synthase, in the shikimate pathway, which functions in plants but not animals. Long-term exposure to GBH can cause toxic effects to the nervous system by affecting neurotransmitter expression, oxidative stress, anxiety, learning and memory impairments. Though Gly safety studies are still ongoing, little is known about the mechanistic processes underlying Gly neurotoxicity. Remarkably, few studies examined how the acceptable daily intake (ADI) dosage affects n