Topic: miniscope calcium imaging

Memory-updating is critical in dynamic environments because updating memories with new information promotes versatility. However, little is known about how memories are updated with new information. To study how neuronal ensembles might support memory-updating, we used a hippocampus-dependent spatial reversal task to measure hippocampal ensemble dynamics when mice switched navigational goals. Using Miniscope calcium imaging, we identified neuronal ensembles (co-active neurons) in dorsal CA1 that were spatially tuned and stable across training sessions. When reward locations were moved during a

Atypical sensory processing affects approximately 90% of individuals with autism spectrum disorder (ASD) and has been recently considered a core ASD symptom. In accordance with neurophysiological findings in human subjects, preclinical studies have found altered activity of primary sensory neocortices and sensory association areas following sensory stimuli and perceptual paradigms in several genetic mouse models of ASD. Attention deficits are a common comorbidity of autism and may impact other symptoms. Indeed, recent research suggests that alterations in attention and sensory processing are i

Animals possess the ability to infer knowledge from experience of others, the social transmission of food preference (STFP) in rodents being a prevalent laboratory model of such memory. The neurobiological mechanisms underlying SFTP, as well as the relationship between individual and social memory acquired in the same animal, remain poorly understood. The goal of the present study was to investigate these questions at the cellular level. For this purpose, we used the STFP paradigm in mice, training them to form both short-term and long-term food preference memory. Using c-Fos immunohistochemic