Topic: mIPSCs

It is well known that dopamine is a significant player in regulation of various forms of glutamatergic synaptic plasticity. In particular, activation of D1/D5 dopamine receptors was shown to increase the magnitude of hippocampal excitatory long-term potentiation (LTP) (Hansen and Manahan-Vaughan, 2014). We have also demonstrated that D1/D5 dopamine receptors supports NMDA-dependent LTP selectively in st. oriens of the CA1 region (Brzdak et al., 2019). While involvement of dopamine receptors, especially D1/D5, in the excitatory plasticity is well established, their role in the GABAergic plastic

Mutations in the presynaptic adhesion protein Neurexin-1 (NRXN1) have been repeatedly implicated in cases of autism, schizophrenia, and ADHD. The excitation to inhibition (E:I) imbalance hypothesis posits that behaviours associated with neurodevelopmental disorders such as autism may be driven by the disturbed balance of excitation and inhibition in the cortex. We aimed to identify and characterise the effect of Neurexin-1 mutations on the E:I balance in autism-associated cortical circuits.To assess the effect of Nrxn1 alpha KO on synaptic transmission, whole-cell electrophysiological recordin