Topic: miR-16

Introduction: Early life stress (ELS) significantly increases predisposition to depression. Here, we examined whether the restoring effects of treatment with the fatty acid amide hydrolase (FAAH) inhibitor URB597, which elevates anandamide levels, are associated with alterations in microRNAs (miRNAs) related with depression and whether specific miRNAs have a crucial role in the antidepressant-like effect of URB597. Methods: In experiment 1, male rats were exposed to ELS using the "Limited Bedding and Nesting" paradigm from postnatal day (P)7 to P14. During P45 to P60 (late-adolescence), URB59

Alzheimer’s disease (AD) is the most prevalent ageing-associated neurodegenerative disease. Deep brain stimulation is a novel therapeutic approach, but long-term effects remain unknown. We previously demonstrated that acute intracranial self-stimulation (ICSS) in medial forebrain bundle (MFB) improves the acquisition but not 72-hour retention of a spatial learning task and regulates expression of specific miRNAs in a rat AD model. This study aims to analyse the effect of a chronic MFB-ICSS treatment on spatial memory and miRNA serum expression levels in a rat AD model by streptozotocin (STZ) i