Topic: miRNA sequencing

Alzheimer's Disease (AD) is a complex and progressive neurodegenerative disorder that affects millions of people worldwide. However, current treatments and diagnostic methods are ineffective in early detection and intervention. Recently, researchers have focused on the dysregulation of small non-protein-coding microRNA (miRNA) and the associated post-transcriptional gene alteration in AD. Biofluids, such as serum and cerebrospinal fluid, contain miRNAs that can be identified and quantified. The project aims to identify circulating miRNAs within serum and CSF, which can be used as non-invasive

Major depressive disorder (MDD) is a debilitating disorder whose etiology remains unclear. Small RNA molecules, such as microRNAs (miRNAs), have been implicated in MDD, where they display differential expression in the brain and periphery. Hence, numerous studies have identified altered gene expression and changes in anterior cingulate cortex (ACC) activity in MDD, which appear to be related to antidepressant treatment response. Here, we quantified miRNA expression by small RNA sequencing in the ventromedial prefrontal cortex (vmPFC) of individuals with MDD/suicide and healthy controls. miRNA