Topic: mirtazapine

Maternal depression presents risks to both fetal and child development. While treating maternal depression with antidepressants during pregnancy can alleviate the condition, it also has implications for the development of the offspring. Our study aims to explore the impact of maternal depression and/or prenatal antidepressant treatment on offspring neuronal excitability.We implemented an animal model of maternal depression through chronic and unpredictable stress exposure. Mirtazapine served as the chosen antidepressant. Four experimental groups were used: no stress with vehicle, stress with v

The aim of the study was to determine the effect of chronic unpredictable stress (CUS) and maternal mirtazapine treatment on the pro-inflammatory cytokines IL-6 and TNF-α in the plasma of dams and their adolescent offspring (PP50) of both sexes.In the present study, mothers (n = 6-8/ group) and adolescent offspring (n = 6-8/ group) were divided into 4 groups: no stress+vehicle, no stress+mirtazapine, stress+vehicle, stress+mirtazapine. Dams in the stress group were exposed to CUS for a total of 3 weeks. Females from each group were then mated and treated from the 10th day of gestation to the 2

Mirtazapine (MTZ) is a racemic antidepressant drug, consisting of its S(+) and R(-) - enantiomers in a 50:50 mixture. MTZ has been investigated for its potential in the treatment of Rett syndrome, a neurodevelopmental disorder affecting 1/10.000 young females worldwide. However, the mechanisms of action of MTZ are still unclear. To gain new insights into the pharmacological effects of MTZ, the in-silico prediction of novel targets for MTZ represents a valuable approach. S-MTZ and R-MTZ chemical structures were downloaded from PubChem database to perform a screening of S-/R- MTZ versus 25.717 h

Antidepressant treatment during pregnancy may endanger neurodevelopment of the offspring. Cellular parameters (hippocampal homeostasis) and physiological parameters (behavioral aspects) in the offspring of Mirtazapine treated and depressed mothers are not yet fully described. We evaluated changes in cellular calcium homeostasis (Fura2AM) and CaV1.2 expression, presence of mitochondrial superoxide radicals (MitoSOXTM) together with behavior of developing pups.As an experimental model of perinatal depression we used pre-gestational exposure to chronic unpredictable stress followed by Mirtazapine

We previously reported that pregestational chronic unpredictable stress (CUS) and prenatal treatment with the antidepressant mirtazapine alter offspring anxiety and spatial memory (Viñas-Noguera et al. PLoS One 17: e0255546, 2022). The present study was designed to investigate the potential involvement of dopamine transmission in these behavioral changes. Maternal CUS and mirtazapine were administered as previously described. Adult offspring were anesthetized with chloral hydrate and electrodes were placed in the ventral tegmental area. Dopamine neurons were detected and recorded. We found no