Topic: Mismatch negativity

According to the Accumulation of Evidence (AE) framework, reliable perceptual decisions are forged by integrating the evidence provided by each sensory sample independently of other samples. However, that framework, grounded on the mathematical formulation of the Sequential Ratio Probability Test (SPRT), does not consider that sensory samples can be conditionally dependent (i.e. partially redundant). Partial redundancies are ubiquitous in naturalistic environments. In such case, the normative framework is what we call the Accumulation of Unpredicted Evidence (AUE). In AUE, the current belief i

Schizophrenia is a neuropsychiatric disorder that is strongly associated with impairments in both basic sensory processing and higher cognitive functions. One of the most robust findings is that Schizophrenia patients have deficient sensory processing and impairment can be captured by the reduced “mismatch negativity” (MMN), which is an event-related potential that occurs when a sequence of repetitive stimuli is interrupted by occasional oddball stimuli. Although MMN is the biomarker of Schizophrenia and robustly translational across species, the underlying mechanisms of MMN are not clear. To