Topic: mitochondrial structure

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that causes the degeneration of motor neurons in the motor cortex and spinal cord. Patients with ALS experience muscle weakness and atrophy in the limbs which eventually leads to paralysis and death. NAD+ is critical for energy metabolism, such as glycolysis and oxidative phosphorylation, but is also involved in non-metabolic cellular reactions. In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progr

Propionic acid (PA), a short-chain fatty acid and a metabolite of the gut microbiome, plays a significant role in health but has been associated with various pathologies, including autism spectrum disorder (ASD). Experimental studies in rodents have shown that elevated levels of PA can induce molecular and immune changes similar to those observed in ASD (MacFabe, et al.). However, limited knowledge exists regarding its impact on brain structural integrity. In this study, we examined the effects of a single intraperitoneal injection of PA at a dose of 175 mg/kg on adolescent male Wistar rats. S