Topic: mitral cells

Animals flexibly adjust their behavior to adapt to environmental changes. Mice excel at recognizing odorants in complex sensory conditions; however, little we know about: (1)how sudden changes in stimulus contingency modify odorant representations and (2)how changes in odorant representations causally relate to behavioral adjustments. The olfactory bulb(OB) relays odor-triggered information to higher olfactory areas, including the piriform cortex(PCx). The PCx receives input from association areas(e.g., orbitofrontal cortex) and sends dense feedback that selectively modulates one of the OB out

Recordings from neural populations can be biased towards cells that are spontaneously active, and it is often implicitly assumed that stimulus responses will be unrelated to spontaneous activity. To avoid such biases [1] performed blind whole-cell patch clamp recordings of olfactory bulb mitral cells. Intriguingly, these recordings revealed an inverse relationship between spontaneous and odor-evoked activity: cells that were highly active at baseline were often quiet during odor presentation, while conversely, `silent' cells, quiet at baseline, dominated odor responses. In this study we use a

(Jammal Salameh et al., Science_2024)​​Heartbeat transmission through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we show for the first time that arterial pressure pulsations can directly modulate neuronal activity within the central nervous system via baroreceptive transduction. We recorded local-field-potentials (LFP) within the rat olfactory bulb (OB) using a semi-intact, perfused nose-brain preparation, while monitoring the pressure pulsations induced by the peristaltic perfusion pump that in our setup operated within the physiological range of hea

PCD mice suffer the postnatal death of cerebellar Purkinje neurons and mitral cells of the olfactory bulb (OB). They are also defective in IGF1, but little is known about other neurotrophic factors, which may act as neuroprotective molecules.The expression of different neurotrophic factors (IGF1, BDNF, VEGF-A and VEGF-B) was analyzed by qPCR and ELISA around cerebellar and bulbar degenerations of PCD mice. Then, we applied two different therapies depending on the affected region.1. We refined healthy bone marrow transplants to reduce the degeneration of mitral cells. PCD mice were transplanted

Vasopressin (VP) cells in the rat olfactory bulb (OB) have unique features compared to other types of external tufted cells, with olfactory nerve input inhibiting them and added cholinergic neuromodulation enabling them to fire. However, how VP modulates bulbar synaptic transmission to facilitate social discrimination is still unclear. As first step, we recorded responses to olfactory nerve stimulation and their modulation by VP (1 µM) using electrophysiology as well as 2-photon population Ca2+ imaging in acute OB slices. We first investigated the excitatory middle tufted and mitral cells. In