Topic: MK801

Juvenility (early life) is the crucial stage of neurodevelopment, as the alterations made during this time have been linked to long-term effects on cognition. The brain undergoes significant remodelling involving dendritic arborization, synaptogenesis and neuron proliferation within and between areas, particularly in the hippocampus, which plays a vital role in spatial memory processing. Spatial memory processing ability continues to develop alongside hippocampal maturation particularly before puberty. The N-methyl-d-aspartate (NMDA) type of glutamate receptor channel is essential for activity

Early life aversive experiences influence brain development, contributing to the emergence of psychiatric diseases, such as schizophrenia and major depression. Most of the inhibitory neurons in the thalamus are parvalbumin-expressing (PV+) cells located in the thalamic reticular nucleus (TRN). Alterations of PV+ interneurons, some of them mediated by perineuronal nets (PNNs), have been related to these psychiatric diseases. We have developed two models of early life aversive experiences on the TRN of adult mice. We have used a double-hit (DH) model in male mice combining an injection of the NM

During Cerebral ischemia/reperfusion injury (I/RI), NMDA receptor activity increases, leading to an excessive entry of sodium and calcium, which damages neurons. Therefore, deletion of NMDA receptor subunits may reduce cell death induced by acute brain injury. MK801 is a non-competitive NMDA receptor antagonist that can block NMDA ion channels. In this experimental study, Wistar rats were divided into 6 groups:Sham, I/R, I/R+NMDA (0.5 mg/kg, IV), I/R+MK801 (0.5 mg/kg, IV), I/R+NMDA+ electrophysiology, and I/R+MK801+ electrophysiology. The acute cerebral ischemic injury was induced in rats by o

NMDA receptor antagonists, such as MK801, produce hyperlocomotion and affect the dopamine (DA) system by increasing ventral tegmental area (VTA) activity and enhancing DA release in many regions of the rat brain. NMDAR antagonists also enhance the power of high-frequency oscillations (HFO) in cortical and subcortical areas. The olfactory bulb (OB), a generator of NMDAR-enhanced HFO, contains DA receptors (D1R/D2R) and periglomerular DA neurons. However, the role of DA in the OB in the modulation of MK801-enhanced HFO and locomotion is unknown. Selective DA agonists (SKF38393, quinpirole) and a