Topic: morphological reconstruction

The full-length amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is ubiquitously expressed in a large majority of neurons, including GABAergic interneurons (INTs). Recent studies showed evidence of disrupted hippocampal plasticity in conditional APP KO of GABAergic forebrain neurons (Mehr et al, 2020). However, the physiological functions of APP at inhibitory synapses remain to be defined. We to study the role of APP at inhibitory synapses onto CA3 pyramidal cells (PCs) as well as on the overall inhibitory balance within the CA3 network. We combine slice electrophysio

The substantia nigra pars reticulata (SNr) is a primary output for basal ganglia signalling. It plays an important role in motor control, integrating inputs from upstream structures in the basal ganglia, before sending organised projections to a wide range of targets in the midbrain, brainstem and thalamus. Here we present a detailed in silico model of the mouse SNr, including its afferent inputs. The electrophysiological and morphological properties of SNr neurons are characterised in acute brain slices via whole cell patch-clamp and morphological reconstruction. Using reconstructed morpholog