Topic: motor neuron progenitors

Peripheral nerves are highly susceptible to injuries. Severe nerve injuries with complete disruption in the nerve continuity need surgical intervention; injuries with nerve substance loss need a nerve substitute to fill the gap. Tissue engineering and regenerative medicine techniques have developed several artificial nerve substitutes of natural or synthetic origins to face this issue.In the present study, electrospun nanofibrous membranes composed of polycaprolactone (PCL) and polyaniline (PANI) blend, further doped with camphor-10-sulfonic acid (CSA), were prepared in random and aligned orie

Amyotrophic lateral sclerosis (ALS) involves progressive loss of upper and lower motor neurons, leading to paralysis and death within 5-year post-onset. To test if motor neuron progenitors (MNPs) are prospective for rescuing motor function in ALS patients, we derived MNPs from human bone marrow stromal cells (hBMSCs) and used SOD1G93A mutant mice to model ALS. The hBMSC-MNPs were transplanted to (i) the lateral ventricles of neonates (postnatal day 8) or (ii) the spinal cords of adults (P50-60). In the neonatal model, the hBMSC-MNPs survived in the cerebral cortex and extended axonal fibers in