Topic: motor reflexes

Antidepressant treatment during pregnancy may endanger neurodevelopment of the offspring. Cellular parameters (hippocampal homeostasis) and physiological parameters (behavioral aspects) in the offspring of Mirtazapine treated and depressed mothers are not yet fully described. We evaluated changes in cellular calcium homeostasis (Fura2AM) and CaV1.2 expression, presence of mitochondrial superoxide radicals (MitoSOXTM) together with behavior of developing pups.As an experimental model of perinatal depression we used pre-gestational exposure to chronic unpredictable stress followed by Mirtazapine

A physical impact to spinal cord causes a temporary motor areflexia below lesion during the clinical phase known as spinal shock. Spinal shock remains a quite mysterious phenomenon mainly due to the lack of a consistent preclinical model to study the early functional consequences of injury without the inevitable use of anesthesia, which in turn affects spinal excitability. In this study, our custom-made micro impactor provides a calibrated impact to the ventral surface of the thoracic spinal cord of in vitro neonatal rat preparations of entire CNS. Ventral root (VR) recordings continuously tra