Topic: motor responses

The superior colliculus (SC) is a dorsal midbrain structure known for its roles in multisensory integration and motor responses and its dysfunction has been linked to neurodevelopmental diseases. SC is a highly organized structure composed of distinct laminae of diverse neuronal and glial cell types. However, the precise developmental principles instructing the generation of SC cell-type diversity are still unknown. To investigate this, we pursued lineage tracing using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single cell sequencing (MADM-CloneSeq) and in si

Previous studies have suggested that the relative importance associated with redundant sensory signals should depends only on their relative noisiness, so as to optimize movement precision (Maximum Likelihood Principle, MLP). As a consequence, whether a goal-oriented hand movement is performed in a seated or standing position should not affect the visuo-proprioceptive sensory weights. To test this hypothesis, we asked healthy subjects to perform visuo-manual coordination tasks both seated and standing. Using virtual reality and quantifying the deviation of the subjects’ motor responses due to