Mouse auditory cortex

…Using chronic calcium imaging in mouse auditory cortex, we show that during this representational drift signal correlations predict future noise correlations, suggesting that stimulus-driven co-activation strengthens effective connectivity via Hebbian-like plasticity. Linear network models reveal that these temporal dependencies between signal and noise correlations emerge only when Hebbian learning balances stochastic synaptic changes, preventing functional degradation

…drift on representational drift.In mouse auditory cortex, neuronal populations respond to stimuli in a clustered manner (Aschauer et al., 2022). Our model, comprising inhibitory and excitatory neurons, reproduces these response patterns, especially under inhibition-dominated conditions. W

Inhibitory neurons are pivotal in shaping neural dynamics, acting as a regulatory mechanism to maintain network stability and enhance sensory processing. Their interplay within neural circuits affects stimulus selectivity, temporal precision, and memory functions. On the other hand, mounting evidence suggests that neural responses to sensory stimuli change over time – a phenomenon termed representational drift. Yet, how inhibitory neurons contribute to representational drift remains largely unknown.Here, we examined the collective statistics of inhibitory and excitatory neurons in layers 2/3 o