Topic: mouse brain

Ongoing neural activity unfolds over intrinsic timescales that vary widely across the brain. The increase in timescales along the sensory-transmodal cortical axis parallels the cortical hierarchy, while diversity of timescales within each area may reflect functional specialization of individual neurons. However, mechanisms that give rise to the diversity of timescales within and across brain areas remain largely unknown. We leveraged a brain-wide dataset of single-neuron activity to characterize the intrinsic timescales across the whole mouse brain. Timescales varied widely across brain region

Patterns of gene expression define the status of a cell in physiological as well as pathological conditions. The interplay of gene promoters and enhancers has been identified as a major mechanism to control specific expression patterns. Furthermore, combinations of enhancer elements with a preferable activity profile together with a small core promoter are starting to be used to drive transcription in gene delivery vectors.However, the identification of enhancers often relies on indirect measures, such as DNA conservation or epigenetic signatures. In addition, functional screens for enhancer a