Topic: mouse hippocampus

Synaptic architecture of a memory engram in the mouse hippocampus

Left-right asymmetry is a fundamental feature of higher-order brain structure and function. Within the mouse hippocampus, properties of synapses between pyramidal cells depend on the hemispheric origin of presynaptic inputs. In the CA3-CA1 connection, right-input synapses in stratum radiatum have larger postsynaptic density (PSD) and higher perforation ratio, expressing lower NR2B subunit density, than left-input synapses. The major histocompatibility complex class I (MHCI) and Paired immunoglobulin-like receptor B (PirB) contribute to this asymmetry, suggesting potential trans-synaptic signal