Topic: mouse pups

Although, the first years of our life are influential in adulthood, we can barely remember detailed memories for events (`episodic memory`) from that time. The underlying reason may be the dramatic changes that the hippocampus undergoes postnatally. Episodic(-like) memory is also known to develop late in rodents. As such, hippocampal-dependent memory starts to emerge from ~3weeks of age. This time window is associated with changes in the molecular composition of neurons and the emergence of hippocampal activity mechanisms implicated in the mature memory (e.g. place cells, replay).In order to u

The ability to lay down detailed and specific hippocampal-dependent memories and the capability to retain these over extended periods of time develops gradually . In mice, adult-like hippocampal-dependent memory starts to emerges ~3 weeks of age. Spatial representations (place, grid head direction cells) emerge with a similar timeline and so does memory replay, the spontaneous repetition of experience-related activity patterns. Memory replay is thought to be key to information communication between the hippocampus and neocortex. It is therefore important to assess the developmental timeline of