Mouse retina

…giant, non-spiking interneurons in the mouse retina. B/K WACs exhibit orientation-selective calcium signals along their long, straight, unbranching dendrites, which contain both synaptic inputs and outputs. In this study, we ident

…We recorded spiking activity from mouse retinal ganglion cells (RGCs) in

…biophysical model of the mouse retina that is primed for gradient-based optimization. Our model is based on the Jaxley software library (Deistler et al. 2024, Bernstein Conference) and JAX machine learning framework. The model consists of a network of Hodgkin-Huxley style neurons, realistic synapse dynamics, an experimentally-informed organization of cells in 3D space, and spatially constrained connectivity. We further implemented a wide v

Recent studies have shown that ON-alpha sustained (ON-αs) retinal ganglion cells (RGCs) exhibit distinct distribution patterns within the mouse retina, with a notable prevalence observed in the temporal region. RGCs rely mainly on presynaptic inputs to create meaningful outputs, however the contribution of postsynaptic RGC processing is unknown. Therefore, we compared the intrinsic spiking properties of nasal and temporal RGCs in the wild-type and degenerated mouse retina. Whole-cell patch clamp experiments were performed to measure the responses of temporal and nasal ON-αs RGCs in wild-type a

…We use the mouse retina as a model system because it allows us to stimulate the circuit precisely with its natural input, patterns of light, and record its natural output, the spike trains of retinal ganglion cells. We harness the power of genetic manipulations and detailed information about cell types to uncover new circuits and discover their role in visual processing. Our methods include electrophysiology, computational modeling, and circuit tracing using a variety of imaging techniques.

To survive in the wild small rodents evolved specialized retinas. To escape predators, looming shadows need to be detected with speed and precision. To evade starvation, small seeds, grass, nuts and insects need to also be detected quickly. Some of these succulent seeds and insects may be camouflaged offering only low contrast targets.Moreover, these challenging tasks need to be accomplished continuously at dusk, night, dawn and daytime. Crossover inhibition is thought to be involved in enhancing contrast detectionin the microcircuits of the inner plexiform layer of the mammalian retina. The A