Mouse thalamus

The thalamus is a highly complex region of the brain, with a multitude of molecularly diverse cell types originating from neural progenitor cells during development in a series of highly temporally and spatially orchestrated events. However, the molecular logic that governs the spatio-temporal lineage trajectories of specification between mature cell types and progenitor cells in the thalamus remains poorly understood. In this study, we aim to investigate the role of transcription factors in specifying neural fate and regulating neural lineage progression in the developing thalamus. Using a co

Gangliosides, complex membrane glycosphingolipids, engage in a variety of inter- and intracellular interactions, and play a crucial role in the pathogenesis of various neurological and neurodegenerative diseases. Another membrane constituent, leptin receptor (LepR), modulates feeding behavior by influencing signaling and integration in many regions of the central nervous system. Studies show that a-series gangliosides alter leptin activity by interacting with LepR The redistribution of gangliosides can also influence the regulation of the Na⁺,K⁺-ATPase (NKA) function, whereas leptin pathways c