Topic: movement sequences

Understanding the basal ganglia's role in initiating and executing action sequences is crucial for treating Parkinson's disease (PD). Recent experimental data challenge the classical model attributing pro- and anti-kinetic functions to direct and indirect pathways of the basal ganglia. To better understand movement-related neuronal activity in the basal ganglia, we performed large-scale electrophysiological recordings with Neuropixels probes in awake, behaving mice in the dorsomedial and dorsolateral striatum (DMS and DLS, respectively). We used the MitoPark mouse, a genetic model of PD, to in

Consecutive training on different movement sequences performed with the same motor effectors often leads to retroactive interference - obstructing memory for the initially trained sequence but not for the second. However, in the context of hippocampal-system dependent memories, a poor learning experience, one whose behavioral effects would soon decay, can be enhanced if temporally paired with a ‘strong’, consolidation-triggering, experience. The Synaptic Tagging and Capture hypothesis (STC) explains this paradoxical enhancement by suggesting that synapses specifically engaged in a ‘weak’ learn