Topic: MPTP

Parkinson’s disease (PD) has been associated with alterations in neuronal activity in the basal ganglia-thalamocortical network. The motor cortex (M1) is a key node in this network and likely plays a significant role in the expression of impaired movement in PD. Altered neuronal activity in M1 has been reported and characterized at the single-unit level in PD, however, results are difficult to reconcile under one theoretical model (Doudet et al., 1990; Watts \& Mandir, 1992; Pasquereau et al., 2016). One promising avenue toward a mechanistic understanding of M1 pathophysiology in PD is to inve

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, and it has been reported that α-synuclein accumulates in the gut and then affects the brain along the gut-brain axis. In this study, we used Enterococcus faecium (EF), which was probiotics, that confer health benefits on the host when administered in adequate amounts. C57BL/6 mice, a model of PD induced by MPTP, were treated with EF (1ⅹ1012 CFU/mL). The study showed that motor dysfunction in MPTP-induced PD model mice improved. Additionally, EF was found to decrease the accumulation o

Microglial reactivity is linked with the loss of dopaminergic (DA) neurons in Parkinson’s disease (PD). In this context, we propose that calcium, potentially released by DA dying neurons to the extracellular space, may contribute provoking changes in microglial polarization.Postmortem samples from PD patients exhibited increased microglia-neuron interactions in the Substantia Nigra (SN) when compared with control individuals, indicating a polarization of microglia in this pathological scenario. Besides, MPTP-treated parkinsonian mice also revealed a significant number of polarized microglia to

Parkinson's disease (PD) is characterized by the loss of dopamine-producing neurons and abnormal alpha-synuclein buildup, leading to motor and cognitive symptoms. CD4+ T-cells play a crucial role in PD, influencing disease progression differently across preclinical models. While they aid zebrafish regeneration, they hinder brain recovery in mice. In humans, CD8+ T-cells increase more significantly than CD4+ in PD cases, and their infiltration precedes alpha-synuclein aggregation and neuronal death, suggesting their relevance in disease onset.Here, we set out to uncover which T-cell subsets reg