ePoster · Neuroscience
Modulation of AKT and ribosomal S6 protein phosphorylation by dopamine receptors and cyclic AMP in the developing retina
Roberto Paes-de-Carvalho, Lohan Ximenes, Arthur Barbieri · FENS Forum 2024
Dopamine-dependent cyclic AMP accumulation occurs via activation of D1-like receptors since early development of the chicken retina. Cyclic AMP is an ubiquitous second messenger that regulates several physiological processes including neuronal survival and differentiation. The mTOR pathway is a crucial pathway linking cellular metabolism to protein synthesis. The mTORC1 and 2 signaling complexes are composed of mTOR and distinct proteins, and while mTORC1 is regulated by AKT, mTORC2 is upstream of this enzyme and regulates phosphorylation of its serine 473 residue. Ribosomal protein S6 (RpS6)