mTORC1

Autism spectrum disorder (ASD) is a complex and highly prevalent neurodevelopmental disorder. ASD exhibits significant heterogeneity in genotypes and phenotypes. In recent years, dysregulation of protein synthesis has emerged as a converging mechanism in ASD. Here, to explore altered translation in ASD, we used induced pluripotent stem cells (iPSCs) which have emerged as a promising cellular tool for disease modeling. Patient relevant mutations in FMR1, PTEN, and TSC2, that cause dysregulated protein synthesis, were introduced into iPSCs derived from healthy donors via CRISPR/Cas9. Then, iPSCs

…signalling complexes: mTOR complex 1 (mTORC1) and 2 (mTORC2). Manipulating mTORC1 signalling in animal models has shown that this pathway has key roles in neurogenesis, and mTORC1 hyperactivation during neurodevelopment causes a group of disorders known as mTORopathies. mTORopathies typically involve brain malformations and neurological manifestations like epilepsy. One example is tube

…The mTORC1 and 2 signaling complexes are composed of mTOR and distinct proteins, and while mTORC1 is regulated by AKT, mTORC2 is upstream of this enzyme and regulates phosphorylation of its serine 473 residue. Ribosomal protein S6 (RpS6)

Neurotoxins are numerous groups of drugs that lead detrimental effects on the neuronal system and caused the cognitive and neurological impairments. Intracellular signaling and homeostasis can disturb by those toxins. Lysosomes are crucial organelles to digest waste disposal and supply the essential materials. It is still unknown to connection between lysosomal homeostasis and neurological dysfunction. Here, we investigated how to attenuate the neurodegeneration though managing lysosomal function. After treatment of hydroperoxide as known as one of the neurotoxins, N2A cell proliferation decre

…Target Of Rapamycin Complex 1 (mTORC1), a central regulator of protein synthesis

…Here we focus on the Rptor/mTORC1 signaling pathway and its role in RGP cell lineage progression and cortical neurogenesis. By using Mosaic Analysis with Double Markers (MADM)

…trehalose induces autophagy in an mTORC1-independent manner activating the transcription factor EB (TFEB), the master transcriptional regulator of autophagy-lysosomal biogenesis. Accordingly, several studies indicated that treh