Topic: multi-electrode array recordings

Understanding the neural mechanisms governing different states of cortical processing is pivotal for unraveling the cognitive processes underpinning perception. Observing freely-behaving animals offers a naturalistic environment that elicits a manifold of dynamically changing cognitive and behavioral states, and thus reflects real-world scenarios more accurately than under anesthesia or head-fixed conditions. In this study, we explore the interplay between evoked and spontaneous population activity and its impact on auditory processing within the primary auditory cortex of freely-moving gerbil

Mutations in SYNGAP1 gene represent one of the most frequent genetic causes of neurodevelopmental disorders. De novo heterozygous SYNGAP1 variants are associated with a complex clinical presentation, characterized by intellectual disability, epileptic encephalopathy, hyperactivity, sleep and language disorder, and autism spectrum disorder. The SynGAP protein is highly expressed in excitatory neurons and localized mainly to synapses as a core post-synaptic density protein. Here, it acts as a potent regulator of the RAS/ERK signalling pathway, regulating synaptic plasticity and neuronal homeosta