Topic: multi-unit electrophysiological recordings

Voluntary movement in animal is regulated be the sensorimotor cortex. The cortex generates the motor command as well as signals to increase the weight of relevant sensory information (sensory gating) that are both essential for the realization of adapted and coordinated movements. The corticospinal tract (CST) is the most direct pathway conveying these signals. Our previous work on anesthetized mice has shown that the lumbar projecting CST induces mainly the modulation of sensory information rather than the direct control of muscle contraction. The aim of our study is to identify the implicati

An influential model of addiction proposes that repeated exposure to addictive drugs results in overvaluation of drug cues and long-lasting cue-drug associations, which results in heightened motivation to seek drugs upon exposure to these cues. This model focuses on the role of midbrain dopamine neurons in forming these associations, known as cue reactivity. However, the neurophysiological responses of non-dopamine neurons to cues predicting opioids vs. natural rewards have not been examined previously. Multi-unit electrophysiological recordings were collected from the midbrain of adult Long-E