Multiple System Atrophy

…including Lewy body disease (LBD), multiple system atrophy (MSA), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), a

Multiple System Atrophy (MSA) is a progressive neurodegenerative disorder due to the loss of various neuronal populations, including the GABAergic and the dopaminergic systems in the striatum and in the midbrain. The resulting degeneration of the nigro-striatal circuit is responsible for a severe neurological involvement characterized by parkinsonism and cerebellar phenotypes. The neuropathological hallmarks of MSA consist of alpha-synuclein aggregations in oligodendrocytes and neurons. No disease-modifying therapy is available for this disorder, resulting in a reduced life-span of affected pa

Neurological diseases such as Multiple System Atrophy (MSA), Parkinson's disease, Lewy Body Dementia, and Pure Autonomic Failure lead to severe dysfunctions of the autonomic nervous system, resulting in neurogenic orthostatic hypotension. Current treatments remain limited, and certain therapies, such as dopamine replacement, may worsen symptoms. Our recent research revealed how a neuroprosthetic intervention such as epidural electrical stimulation (EES) of the thoracic spinal cord regulates blood pressure, leading to the development of a neuroprosthetic baroreflex effective across multiple spe

…ET, as compared with subjects with multiple system atrophy (MSA), a well-established cerebellar neurodegeneration. Cases with ET (n = 29), MSA (n = 7), and non-demented control cases without any movement disorder (n = 22) were selected from the