Topic: myelin

Brain banks provide small tissue samples to researchers, while gross-anatomy laboratories could provide complete brains, but these are preserved with solutions appropriate for gross-dissection, different from the classic neutral-buffered-formalin (NBF) used in brain banks. Our previous work in mice showed that two gross-anatomy laboratory solutions, a saturated-salt-solution (SSS) and an alcohol-formaldehyde-solution (AFS), preserve antigenicity of the main cellular markers. Our goal is now to compare the histology and antigenicity preservation of human brains fixed following: 1-brain bank pra

Myelin, produced by oligodendrocytes (OLs), is a lipid-rich structure that wraps axons, facilitating the saltatory conduction and providing metabolic support to neurons. Myelin is a highly adaptable structure whose role in regulating synaptic transmission in the healthy and diseased brain have not been extensively examined and may be relevant for understanding neuronal dysfunctions associated with myelin-related disorders. Here, we investigated excitatory (EPSCs) and inhibitory (IPSCs) post-synaptic currents in layer IV of the somatosensory (barrel) cortex using a cuprizone-induced demyelinati

Alzheimer's Disease (AD) are characterized with the accumulation of hyperphosphorylated tau protein and Aβ and neuroinflammation. Disrupted myelin has been observed in the brains of AD patients before the onset of symptoms. However, it remains unknown the function of myelin-forming cells in AD pathogenesis. Oligodendrocyte precursor cells (OPCs) are the source cells of myelin-forming cells in the central nervous system (CNS). In this study, we observe an abnormally enhanced microglial phagocytosis upon in activation of autophagy in OPCs. AD transgenic mice harboring defective autophagy exhibit