Topic: myelin basic protein

The corpus callosum (CC) is a wide and thick nerve tract in the brain. It is the largest white matter structure in the human brain, measuring approximately 250mm in length, and consisting of 200-300 million myelinated axons. According to the World Health Organization (WHO), the world's population is getting older. Aging is one of the main risk factors for neurodegenerative diseases. Brain aging involves mitochondrial dysfunction, dysregulated energy metabolism, altered neuronal activity, and inflammation. Changes in white matter metabolism during aging are poorly understood. In this study, we

Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most common complications associated with prematurity. It may lead to life-lasting cognitive, sensory, motor and behavioral impairments and it has no successful treatment. Nevertheless, it has been suggested that early behavioral intervention programs may have beneficial effects in premature infants. Accordingly, we have analyzed the effects on neuronal damage and behavioral impairment of early exposure to an enriched environment (EE) of a murine model of GM-IVH. GM-IVH was induced by intraventricular collagenase administration

In preterm infants, hypoxic injury to premyelinating oligodendrocytes leads to failure of oligodendroglial maturation causing long-term neuromotor disabilities. As astrocytes influence oligodendrocyte maturation, this study aimed to analyze the transcriptomic changes in astrocytes after hypoxic injury, to identify possible pathways influencing myelination. Human fetal neural stem cell-derived astrocytes, expressing astrocyte-specific glial fibrillary-acidic protein (GFAP) and excitatory amino acid transporters (EAAT1 and EAAT2), were exposed to hypoxia (0.2% oxygen) and normoxia (20% oxygen) f

Spinal cord injury represents a complex and serious medical condition characterized by damage to the spinal cord, causing profound functional impairment. The consequences of such an injury may include paralysis, loss of sensation, and disruptions in vital bodily functions, such as bladder and bowel control. The renin-angiotensin system, predominantly acting through the AT1 receptor, regulates blood pressure and hydro-electrolytic balance. However, the AT2 receptor (AT2R) also plays a crucial role, especially in processes related to neuroregeneration. In the present study, the AT2R was stimulat