Topic: Myelin repair

In the recent years, several pro-myelinating agents have been identified (Melchor et al., 2019). Among them, clemastine fumarate an anti-muscarinic compound, has been recognized as a potent agent promoting anatomical and clinical recovery in rodents (Mei et al., 2014, Cordano et al., 2023) and primary efficacy in clinic (Green et al., 2017). Although the clinical trial REBUILD showed reduced visual evoked latencies (VEP) in RRMS patients treated with clemastine, the impact of clemastine on myelin repair in the absence of post-mortem validation, remained elusive. We took advantage of a recently

Oligodendrocyte precursor cells (OPCs) serve as progenitors for oligodendrocytes (OLs) throughout their life, contributing to developmental and adaptive myelination, as well as myelin repair. OPCs are known to make synaptic and extra-synaptic contacts with axons, but the mechanisms by which they integrate the information relayed by the neuronal activity into Ca2+ signals, which in turn influence their fate and survival, are still unclear. Using newly developed transgenic mouse lines to express genetically encoded Ca2+ sensors in OPCs, we performed 2-photon microscopy in the somatosensory corte