Topic: myelin sheaths

Neonatal hypoxic ischemia (HI) causes motor impairment affecting daily activity. Rehabilitation is frequently implemented to improve motor performance, but its effects are often insufficient for acquiring fine motor coordination. Recently, myelin plasticity has been pointed out necessary for improving motor skills. However, the significance of myelination for motor improvement after HI remains unclear.To address this issue, we investigated the effect of rehabilitation exercise on myelination in a neonatal HI rat model. We then examined the effectiveness of pharmacological promotion of myelinat

In the central nervous system (CNS), the formation of functional neuronal networks during development depends on the ability of neuroepithelial progenitor (NEPs) to generate neurons and glial cells – oligodendrocytes and astrocytes - in a highly specific manner, both temporally and spatially. In the ventral neural tube, depending on both its concentration and timing of exposure, Sonic Hedgehog (Shh) - released by the notochord and floor plate cells - regulates expression of transcription factors that demarcate distinct NEP domains dedicated to sequentially generate specific neuronal and glial