Topic: N6-methyladenosine (m6A)

The epitranscriptome, the reversible and dynamic regulation of RNA by chemical modifications, plays a vital role in governing RNA's fate and function. N6-methyladenosine (m6A) is the most abundant and functionally relevant RNA modification, affecting mRNA splicing, transport, storage, stability, translation, and decay. The Fat Mass and Obesity-related protein (FTO) is an m6A eraser that plays a role in memory formation in the brain. Our study aimed to investigate FTO's role in neurons and the modulation of its expression. We found that FTO is widely expressed in the mouse brain and increases d

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and the accumulation of abnormal proteins, such as beta-amyloid plaques, in the brain. Epitranscriptomics, a branch of molecular biology, studies chemical modifications to RNA molecules and their impact on gene expression and cellular function. Among these modifications, N6-methyladenosine (m6A) plays crucial roles in various aspects of RNA metabolism, including RNA splicing, stability, translation, and localization. Dysregulation of m6A modification has been implicated in the development an

Alterations of N6-methyladenosine (m6A) RNA modifications are responsible for a platter of structural and functional changes in healthy and cancerous cell states. Even though several studies have linked m6A to the onset and development of tumors, very few have examined transcriptome-wide m6A landscape of long non-coding RNAs (lncRNAs) in cancerous cells, including gliomas. This work aims to explore and elucidate lncRNA m6A alterations and expression in glioma stem cells, U87-MG cells and glioma patients. We utilized four cell lines (NCH421k, NCH644, NCH690, U-87 MG), along with 16 glioblastoma