Topic: NAc

Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, predominantly within the substantia nigra pars compacta (SNc) region. Dysregulation of FoxO1 has been implicated in various neurodegenerative diseases, including Alzheimer's disease and PD, yet the precise underlying mechanisms remain largely elusive. In this study, we investigated the impact of α-synuclein pre-formed fibrils (PFF) treatment on BV-2 microglial cells to elucidate alterations in molecular properties and neuronal degeneration. Surprisingly, our find

Deep brain stimulation (DBS) targeting the medial forebrain bundle (MFB) is emerging as a promising intervention for treatment-resistant depression. Our study systematically investigated the NA system in a depression model and explored the modulatory effects of mfb-DBS on this system.Using Flinders Sensitive Line (FSL) rats as a depression model and Sprague Dawley (SD) rats as controls, we examined the spatial distribution and myelination of NA fibers within the mfb under confocal microscopy, monitored real-time in vivo NA release in response to mfb-DBS in the mPFC and NAC during 6 different s