Topic: negative symptoms

In schizophrenia, disrupted perceptual processes are attributed to both hallucinations and delusions in positive symptoms [1, 2]. However, it remains unclear how top-down and bottom-up processes are represented across a visual hierarchy related to distinct symptoms, such as hallucinations, delusions, and negative symptoms. Our goal is to identify the visual areas involved in aberrant top-down and bottom-up processes that contribute to distinct symptoms in schizophrenia. To investigate this, we conducted a functional magnetic resonance imaging (fMRI) experiment with a perceptual decision-making

Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of schizophrenia is essential. To address its multifactorial etiology, we developed a new 3-hit mouse model. This model was mostly concealing the glutamatergic deficit hypothesis of the pathology (underlying cognitive and negative deficits). Thus, a genetic susceptibility (serine racemase deletion) was associated to environmental stress (24h maternal separation at 9-day of age) and pharmacological treatment (phency

Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, is probably the most well-studied; yet, little is known about the altered psychological processes underlying this behavioral deficit. Despite the complex nature of social behavior, social interaction is indeed often simplified to a single readout parameter (e.g., total time spent in social interaction) that has limited explanatory power. Therefore, we developed a comprehensive ethogram of the social, as well as non-social (i.e., self-oriented behaviors and arena