Topic: Nerve Growth Factor

Our previous study found that ectomesenchymal stem cells derived from human pluripotent stem cells (hPSC-EMSCs) exhibited higher neuroprotective potential than hUC-MSCs, as evidenced by a more significant reduction in lesion size and apoptosis in rat brains after hypoxia-ischemia (HI). Moreover, in vitro studies demonstrated that hPSC-EMSC-derived conditioned medium (CM) had neuroprotective and neurorestorative effects through the promotion of anti-apoptosis, neurite growth and neurogenesis. In this study, we discovered that hPSC-EMSCs and hUC-MSCs expressed differential secreted factors by ut

The Nerve Growth Factor (NGF) has been linked to Alzheimer’s disease (AD) due to its survival-promoting activity on cholinergic neurons in the basal forebrain, whose demise contributes to cognitive decline in AD. Related to that, we demonstrated that intranasal administration of a painless NGF (hNGFp) displays a wide beneficial effect in the brain of an AD mouse model (5xFAD) by rescuing not only cholinergic defects, but also cortical and hippocampal beta-amyloid depositions and memory alterations. Since hNGFp only acts on Tropomyosin receptor kinase A (TrkA), and non-cholinergic neurons do no

Neurotrophic activity constitutes a crucial factor in the recovery from neurological injuries and is impaired in neurodegenerative disorders. Preclinical studies of neurotrophic factors to improve outcome of neurodegenerative diseases have yielded promising results. However, due to the complexity of these therapies, the clinical translation of this approach was so far not successful and more feasible treatments with neurotrophic activity may be promising alternatives. Therefore, highly sensitive and robust assays for compound screening are required. Nerve growth factor (NGF) is known to induce

Diabetic retinopathy (DR), a common complication of diabetes, is a leading cause of blindness among working-age individuals worldwide. Traditionally, DR was considered primarily a microvascular complication, categorized as either nonproliferative or proliferative based on neovascularization presence. However, emerging evidence suggested that neurodegeneration plays a crucial role in DR beyond its microvascular aspects. Neurotrophic factors, such as nerve growth factor (NGF), have significant effects on neuronal survival. In the visual system, NGF influences retina and optic nerve development,