Topic: nerve growth factor (NGF)

Methamphetamine (MA) is a highly addictive psychostimulant abused worldwide that causes long-term behavioral changes that are linked to changes in the brain. The third trimester and adolescence are critical periods of development as the body undergoes dramatic changes and becomes more sensitive to the effects of the drug. This study aimed to investigate the effect of MA exposure during the first 12 postnatal days of laboratory rats, corresponding to the human third trimester, on hippocampal neurotrophin levels in adolescence. Exposure was performed either directly (daily subcutaneous injection

Choline Acetyltransferase (ChAT) serves as a reliable marker for motoneurons, including those within the oculomotor (OCM) system located in the brainstem. Although ChAT activity increases in spinal cord motoneurons during postnatal development, the evolving expression profile of this enzyme within the OCM system across various life stages remains unexplored. Previous investigations have indicated an elevation in nerve growth factor (NGF) expression in the spinal cord during postnatal development, mirroring ChAT patterns. Ocular motoneurons exhibit a distinct dependence on NGF due to the consti