Topic: Nestin-Cre

Noggin is a glycosylated protein that can act as an inhibitor of bone morphogenetic protein (BMP) and has been shown in animal studies to improve functional recovery after spinal cord injury (SCI). Its mechanism of action promotes the regeneration and repair of damaged spinal cord tissue by regulating the differentiation and growth of glial cells and regulates the interaction between neurons and glial cells. However, very few studies on endogenous Noggin have been reported, and the available studies are limited to the therapeutic effects of exogenous Noggin. Therefore, we explored the expressi

Progranulin (PGRN), encoded by the GRN gene, is a potent neurotrophic and anti-inflammatory factor expressed by neurons and microglia. Heterozygous or homozygous loss-of-function mutations in the human GRN gene cause frontotemporal dementia and neuronal ceroid lipofuscinosis, respectively. Previous studies also demonstrated exacerbated consequences in Grn-deficient mice after experimental traumatic brain injury (TBI). However, the relative contribution of neuronal or microglial PGRN in neuroprotective and anti-inflammatory effects is still elusive. Here, we tested the hypothesis that transgeni