Topic: network excitability

Traumatic brain injury (TBI), a leading cause of acquired epilepsy, results in primary cellular injury as well as secondary neurophysiological and inflammatory responses which contribute to epileptogenesis. I will present our recent studies identifying a role for neuro-immune interactions, specifically, the innate immune receptor Toll-like receptor 4 (TLR4), in enhancing network excitability and cell loss in hippocampal dentate gyrus early after concussive brain injury. I will describe results indicating that the transient post-traumatic increases in dentate neurogenesis which occurs during th

Neuronal cultures in vitro are a versatile system for studying the basic properties of individual neurons and neuronal networks that recently gained additional attention as a precision medicine tool. Mature neuronal cultures exhibit synchronized collective dynamics called network bursting. This activity can provide insights into the network's cellular composition, network topology, or any underlying pathological processes. An effective method to investigate network bursting dynamics is to map it onto a simplified dynamical model, and then examine the model's dynamic regimes and the characteri