Clonal analysis at single cell level helps to understand neural crest development
Recent research on the neural crest has revealed the multipotency and plasticity of nerve-associated Schwann cell precursors, which can differentiate into diverse cell types, including parasympathetic neurons, neuroendocrine cells, and mesenchymal stem cells. These findings challenge the traditional view of peripheral nerves, highlighting their role as niches for migratory progenitor cells that contribute to tissue formation and regeneration.
↗ Clonal analysis at single cell level helps to understand neural crest development
Adult neurogenesis in mouse hippocampus
Dr. Aixa V. Morales has been working for more than 20 years in the field of Developmental Biology and from 2005, she is the PI of the laboratory on “Molecular Control of Neurogenesis” at Cajal Institute. Along these years, she has contributed to understanding the control of neurogenesis during development, the dorsoventral specification of neural progenitors, and the temporal control of the migration of neural crest cells. More recently, her lab interest moved towards understanding modulation of adult neurogenesis. Her lab current interest is the control of quiescence, as a mechanism of long-term neural stem cell maintenance in adult niches.