Neural perturbations

Understanding how neural perturbations propagate in the nervous system is important for understanding neural dynamics, to elucidate specific circuits, and to reveal how neuroanatomy relates to neural function. Here, we systematically perturb individual neurons in C. elegans while measuring the responses of all neurons in its brain in order to directly measure functional connectivity at brain scale and cellular resolution. Specifically, we measure the sign, strength, direction, and temporal properties of the connections between neurons. We present a preliminary functional connectome, currently

…electrophysiological recordings with neural perturbations. We found that the influence primary visual cortex (V1) and higher visual area LM had on each other was surprisingly variable over time. Both feedforward and feedback pathways

…However, the neural basis for these states, and the contributions of different brain regions to state-dependent decision-making strategies, remains an important open problem. Here we address this challenge by performing a model-based analysis of decision-making data acquired during multi-region laser-scanning inactivation of dorsal cortex. We analyzed optogenetic inactivation data from mice pe