Topic: neural stem/progenitor cells

The C-terminal binding protein 1 (CtBP1) is a ubiquitously expressed, dual-function protein. In the nucleus, it nucleates corepressor complexes that control chromatin-modification and gene expression. In the cytoplasm, it regulates membrane trafficking processes by controlling the membrane fission reaction. Our previous study revealed an involvement of CtBP1 in the control of neural activity‐regulated genes such as BDNF, Arc and Fos in the mature brain. Recently, individuals with a missense mutation in CTBP1 have been reported to have intellectual disability and neurodevelopmental problems. Th

Aims: Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflamm

Neurogenesis requires the coordinated interplay between different cell types within the specialized microenvironment of the neurogenic niche. An important role is played by glia which, among their homeostatic roles, also include modulation of neural stem cells and their progeny.We will share and discuss recent molecular, biochemical and pharmacological data supporting an important role of astroglial cells in the modulation of neurogenesis under both physiological and pathological conditions, including aging and neurodegeneration. Particularly, focus will be on the role of astrocytes and their

Neurogenesis is the process by which dividing neural stem/progenitor cells (NSPCs) produce post-mitotic cells. The balance between self-renewal and differentiation is a highly controlled process under the influence of intrinsic and extrinsic factors. Previous studies have pointed to a model whereby cell fate is largely determined before the last mitosis. However, recent findings indicate that in the cerebral cortex mitochondrial dynamics have an impact on neurogenesis after the last cell division. Daughter cells with high levels of mitochondrial fusion undergo self-renewal, whereas those cells

The transcription factor P73 belongs to the p53 protein family, and its gene encodes two main isoforms: the transcriptionally active TAp73 isoform and the dominant-negative ΔNp73. Both isoforms play pivotal roles in regulating the self-renewal and differentiation of neural stem/progenitor cells, thus play a critical role in brain development during neuronal differentiation. Mutations in TP73 are associated with lissencephaly in humans and severe brain defects in mice. The role of TP73 and its isoforms during neurogenesis in human is still unclear. Aiming to further scrutinize the role of TAP73