Topic: neurofilaments

Our study investigates the potential synergistic effect of regenerative therapy combining electrical stimulation with application of anti-inflammatory drug atorvastatin (ATR) following spinal cord injury (SCI). Using an isoflurane anesthesia, we induced SCI at the T9 segment with a compression device for 15 minutes under a 40g weight. An oscillating field stimulator (OFS) implanted subcutaneously delivered a weak electric current (50 µA), alternating polarity every 15 minutes for 6 weeks to encourage axonal growth from the lesion site. Wistar albino female rats were randomly divided to four gr

Neurofilaments, neuron-specific cytoskeletal proteins, are heteropolymers composed of four subunits: NFL, NFM, NFH, and αINTX. The synaptic population (SNFs) differs from the axonal subgroup and subserves unique functions, such as the maintenance of synaptic integrity and the modulation of neurotransmission. During aging, synapses undergo several modifications, contributing to the worsening of cognitive performances and the so-called age-related memory impairment. Despite that, nothing is known about "senescent" SNFs. Our research aimed to study the age-related expression pattern of SNFs subun