Topic: neurogenic niche

Lifestyle factors exert a significant influence on the structure and function of the brain. These effects are particularly pronounced in the hippocampus, crucial for learning and memory, known for its plasticity and the existence of adult neurogenesis—the generation of new neurons in adulthood. While the enhancing effect of environmental stimulation on adult neurogenesis has been extensively studied, there has been a notable lack of attention to its impact on other cell types within the adult neurogenic niche, such as microglia.In this study, we investigated the effects of environmental stimul

Meninges are a system of three-layered membranes which envelop the Central Nervous System (CNS) at each level of its organization, acting as a protective barrier. Beside this acknowledged role, meninges have emerged as complex structures able to sense, integrate and respond to CNS, external stimuli and injury. Recently, meninges have been suggested as a novel neurogenic niche hosting neural progenitors (NPCs) which can migrate and integrate into the brain cortex. However, their contribution to brain autoimmune disease is still unknown. We aimed to assess the role of meningeal neural progenitor

Neurogenesis requires the coordinated interplay between different cell types within the specialized microenvironment of the neurogenic niche. An important role is played by glia which, among their homeostatic roles, also include modulation of neural stem cells and their progeny.We will share and discuss recent molecular, biochemical and pharmacological data supporting an important role of astroglial cells in the modulation of neurogenesis under both physiological and pathological conditions, including aging and neurodegeneration. Particularly, focus will be on the role of astrocytes and their

The generation of new neurons in the hippocampus, known as adult hippocampal neurogenesis (AHN), is a distinctive plastic process that plays an important role in mechanisms of learning, memory, and mood regulation. Various factors intricately regulate the proliferation, survival, and differentiation of newborn neurons, shaping the neurogenic niche. Microglia and astrocytes, prominent niche components, actively regulate AHN. Microglia, acting as vigilant immune sentinels, shape AHN through direct interaction with immature neurons and the release of critical soluble factors. Similarly, astrocyte